Open Access

ARTICLE

Association of hypoxia-inducible factor-1α (HIF1α) 1772C/T gene polymorphism with susceptibility to renal cell carcinoma/prostate cancer

HONGYAN LI^1,#, CHUNLING LIAO^2,#, WENJUAN WENG², HONGZHEN ZHONG², TIANBIAO ZHOU^2,*

1 Department of Nephrology, Huadu District People’s Hospital of Guangzhou, Southern Medical University, Guangzhou, China
2 Department of Nephrology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China

* Address correspondence to: Tianbiao Zhou,
# These authors contributed equally to this work

BIOCELL 2020, 44(2), 257-262. https://doi.org/10.32604/biocell.2020.08826

Received 14 October 2019; Accepted 21 April 2020; Issue published 27 May 2020

Abstract

In this study, we used a meta-analysis method to evaluate the relationship between hypoxia-inducible factor-1α (HIF1α) 1772C/T gene polymorphism (rs 11549465) and renal cell carcinoma (RCC)/prostate cancer risk. We searched for relevant studies (before March 1, 2019) on Cochrane Library, Embase, and PubMed. Studies meeting the inclusion criteria were recruited into this meta-analysis. The outcome of dichotomous data was showed in the way of odds ratios (OR), and 95% confidence intervals (CI) were also counted. In this investigation, there was no association between HIF1α 1772C/T gene polymorphism and susceptibility to RCC in Caucasians, Asians as well as overall populations. In addition, HIF1α 1772C/T gene polymorphism was not found to be relevant to the survival in RCC. Interestingly, the T allele was relevant to prostate cancer risk in all populations, but not in Caucasians and Asians. However, the TT genotype and the CC genotype were not related to prostate cancer susceptibility in Asian, Caucasian, and all populations. In conclusion, the T allele of the HIF1α 1772C/T gene polymorphism was related to prostate cancer risk in the overall populations.

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