Yuhui Zhou^1,2,3,*, Shichang Ju⁴, Qijun Lyu⁴, Hongfei Chen⁴, Xuebiao Du⁴, Aiping Zheng⁴, Wenshun Chen⁴, Ning Li⁴

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.1, pp. 245-259, 2023, DOI:10.32604/fdmp.2023.019971

Abstract It is known that the pore media characteristics of glutenite reservoirs are different from those of conventional sandstone reservoirs. Low reservoir permeability and naturally developed microfractures make water injection in this kind of reservoir very difficult. In this study, new exploitation methods are explored. Using a real glutenite reservoir as a basis, a three-dimensional fine geological model is elaborated. Then, combining the model with reservoir performance information, and through a historical fitting analysis, the saturation abundance distribution of remaining oil in the reservoir is determined. It is shown that, using this information, predictions can be made about whether the considered… More >

Hao Tian, Yongkang Zheng^*, Hanxin Zhang

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.1, pp. 207-222, 2023, DOI:10.32604/fdmp.2023.019790

Abstract In this paper, some typical methods to promote mixing in supersonic combustion are reviewed, and the fluid-dynamic mechanism underpinning the development of the supersonic shear layer in the presence of a streamwise vortex is analyzed through computational fluid dynamics. It is proven that the streamwise vortex-couple method is an excellent approach to enhance mixing. A specific combustor design is proposed accordingly. More >

Mohammad Reza Hajmohammadi¹, Javad Najafiyan¹, Giulio Lorenzini^2,*

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.1, pp. 233-244, 2023, DOI:10.32604/fdmp.2023.019763

Abstract In this study, three computational approaches for the optimization of a thermal conduction problem are critically compared. These include a Direct Method (DM), a Genetic Algorithm (GA), and a Pattern Search (PS) technique. The optimization aims to minimize the maximum temperature of a hot medium (a medium with uniform heat generation) using a constant amount of high conductivity materials (playing the role of fixed factor constraining the considered problem). The principal goal of this paper is to determine the most efficient and fastest option among the considered ones. It is shown that the examined three methods approximately lead to the… More >

Jun Feng^1,2, Tao Bian^1,2,5, Qianpeng Han², Bing Wang^1,3,4,*

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.1, pp. 1-14, 2023, DOI:10.32604/fdmp.2023.018275

Abstract The influence of the width of the circular ring of a car cooling fan on the aerodynamic noise is investigated numerically through the determination of the overall sound pressure level (OASPL). The results demonstrate that when the circular rings cover near 2/3 of the width of the blade tips of the rotor in the axis direction, the rotor has the lowest OASPL and the related total pressure efficiency and flow mass rate are better than the corresponding values obtained for a reference rotor without a circular ring. With increasing the width of the circular ring in the axis direction, the… More > Graphic Abstract

HASSAN M. OTIFI¹, MISHARI ALSHYARBA², MAJED AL FAYI^3,4, AYED A. DERA^3,4, PRASANNA RAJAGOPALAN^3,4,*

Oncology Research, Vol.29, No.3, pp. 217-227, 2021, DOI:10.32604/or.2022.03570

Abstract Targeted therapies are gaining global attention to tackle Renal Cancer (RC). This study aims to screen FPMXY- 14 (novel arylidene analogue) for Akt inhibition by computational and in vitro methods. FPMXY-14 was subjected to proton NMR analysis and Mass spectrum analysis. Vero, HEK-293, Caki-1, and A498 cell lines were used. Akt enzyme inhibition was studied with the fluorescent-based kit assay. Modeller 9.19, Schrodinger 2018-1, LigPrep module, and Glide docking were used in computational analysis. The nuclear status was assessed by PI/Hoechst- 333258 staining, cell cycle, and apoptosis assays were performed using flow cytometry. Scratch wound and migrations assays were performed.… More >

HUAMIN WANG^1,#, YANTING WU^1,#, ZHENLEI WANG^2,#, YUHANG CHEN¹, JINYU MO¹, WEN GUAN¹, YALI ZHANG¹, HONGLIANG YAO^1,*

Oncology Research, Vol.29, No.3, pp. 201-215, 2021, DOI:10.32604/or.2022.03553

Abstract LncRNAs and metabolism represents two factors involved in cancer initiation and progression. However, the interaction between lncRNAs and metabolism remains to be fully explored. In this study, lncRNA FEZF1-AS1 (FEZF1- AS1) was found upregulated in colon cancer after screening all the lncRNAs of colon cancer tissues deposited in TCGA, the result of which was further confirmed by RNAscope staining on a colon tissue chip. The results obtained using FEZF1- AS1 knockout colon cancer cells (SW480 KO and HCT-116 KO) constructed using CRISPR/Cas9 system confirmed the proliferation, invasion, and migration-promoting function of FEZF1-AS1 in vitro. Mechanistically, FEZF1-AS1 associated with the mitochondrial… More >

TAO LIU¹, LIMIN ZHOU¹, LIANBO ZHANG², XIN GUAN³, YI DONG^1,*

Oncology Research, Vol.29, No.3, pp. 189-200, 2021, DOI:10.32604/or.2022.03573

Abstract Many studies have illustrated the significance of long noncoding RNAs in oncogenesis and promotion of breast cancer (BC). However, the biological roles of CCDC183 antisense RNA 1 (CCDC183-AS1) in BC have rarely been characterized. Thus, we explored whether CCDC183-AS1 is involved in the malignancy of BC and elucidated the possible underlying mechanisms. Our data confirmed elevated CCDC183-AS1 expression in BC, which was associated with poor clinical outcomes. Functionally, knocking down CCDC183-AS1 hampered cell proliferation, colony formation, migration, and invasion in BC. Additionally, the absence of CCDC183-AS1 restrained tumor growth in vivo. Mechanistically, CCDC183-AS1 executed as a competitive endogenous RNA in… More >

LEI SUN^1,2, YUE ZHANG³, YUQIN YAO⁴, HONGLIN DU³, YUEHUA ZHANG¹, AIPING FANG^1,2,*

Oncology Research, Vol.29, No.3, pp. 175-187, 2021, DOI:10.32604/or.2022.03550

Abstract Long intergenic non-protein coding RNA 1124 (LINC01124) has been identified as an important regulator of non-small-cell lung cancer. However, the expression and detailed role of LINC01124 in hepatocellular carcinoma (HCC) remain unestablished to date. Therefore, this study aimed to elucidate the role of LINC01124 in the aggressiveness of HCC cells and identify the underlying regulatory mechanism. Quantitative reverse transcriptase-polymerase chain reaction was performed to measure the expression of LINC01124 in HCC. Cell Counting Kit-8 assay, Transwell cell migration and invasion assays, and a xenograft tumor model were used to investigate the function of LINC01124 in HCC cells, and bioinformatics analysis,… More >

DAWEI ZHU^1,#, LEI ZHANG^1,#, XIAOKAI SHI¹, SHENGLIN GAO¹, CHUANG YUE¹, LIFENG ZHANG¹, YU BAI¹, QIFENG WANG², ATSUSHI OKADA³, TAKAHIRO YASUI³, CHAO WANG^1,4, XINGANG CUI^4,5,*, LI ZUO^1,*

Oncology Research, Vol.29, No.3, pp. 159-174, 2021, DOI:10.32604/or.2022.03458

Abstract Identifying prognostic indicators of clear cell renal cell carcinoma (ccRCC) and elucidating the mechanisms underlying ccRCC progression are crucial for improving ccRCC patient prognosis. This study investigated the clinical significance and biological role of Ring finger protein 43 (RNF43) in ccRCC. Two independent cohorts of patients with ccRCC were employed to determine the prognostic significance of RNF43 by immunohistochemistry and statistical analyses. In vitro and in vivo experiments, RNA-seq, and other techniques were used to determine the biological role of RNF43 in ccRCC and related molecular mechanisms. RNF43 expression was commonly decreased in ccRCC specimens, and low expression of RNF43… More >

MESFER AL SHAHRANI^1,2,*, PRASANNA RAJAGOPALAN^1,2, MOHAMMAD ABOHASSAN¹, MOHAMMAD ALSHAHRANI¹, YASSER ALRAEY¹, REEM M. GAHTANI¹, SURESH RADHAKRISHNAN³, KHLOOD DAGREERY⁴

Oncology Research, Vol.29, No.3, pp. 149-157, 2021, DOI:10.32604/or.2022.03539

Abstract Estrogen receptor (ER) α is expressed in a subset of patient-derived acute myeloid leukemia (AML) cells, whereas Akt is predominantly expressed in most types of AML. Targeting AML with dual inhibitors is a novel approach to combat the disease. Herein, we examined a novel small molecule, 3-(4-isopropyl) benzylidene-8-ethoxy,6- methyl, chroman-4-one (SBL-060), capable of targeting AML cells by inhibiting ERα and Akt kinase. The chemical properties of SBL-060 were identified by proton nuclear magnetic resonance (¹ H-NMR), ¹³C-NMR, and mass spectroscopy. In silico docking was performed using an automated protocol with AutoDock-VINA. THP-1 and HL-60 cell lines were differentiated using phorbol… More >