Mathematical Analysis of Novel Coronavirus (2019-nCov) Delay Pandemic Model

In this manuscript, the mathematical analysis of corona virus model with time delay effect is studied Mathematical modelling of infectious diseases has substantial role in the different disciplines such as biological, engineering, physical, social, behavioural problems and many more Most of infectious diseases are dreadful such as HIV/AIDS, Hepatitis and 2019-nCov Unfortunately, due to the non-availability of vaccine for 2019-nCov around the world, the delay factors like, social distancing, quarantine, travel restrictions, holidays extension, hospitalization and isolation are used as key tools to control the pandemic of 2019-nCov We have analysed the reproduction number R-nCov of delayed model Two key strategies from the reproduction number of 2019-nCov model, may be followed, according to the nature of the disease as if it is diminished or present in the community The more delaying tactics eventually, led to the control of pandemic Local and global stability of 2019-nCov model is presented for the strategies We have also investigated the effect of delay factor on reproduction number R-nCov Finally, some very useful numerical results are presented to support the theoretical analysis of the model

than one, then it indicates that 2019-nCov has been continuously increasing. In this model, we have introduced the element of delay. The delay factors are quarantine, place of isolation or vaccination etc. In common epidemiological models, if infection rate is controlled then the disease converges towards the stable positions. In current situation of 2019-nCov, control of infection is nearly impossible, so far have to use the delaying tactics, to overcome the pandemic of 2019-nCov, like social distancing, quarantine, isolation etc. Fortunately, the delay factors or delaying tactics in the modeling are selfstanding and independent of all other types of transmission rates. The strategy of our paper is as follows: In Section 2, we discussed 2019-nCov model with time delay effect. In Section 3, we discussed equilibria of the model. In Section 4, we discussed the reproduction number and its key role describing the 2019-nCov model. In Section 5, we discussed the local and global stability of the model. In Section 6, we discussed numerical results to strengthen the theoretical analysis of the model. In last section, conclusion and future results are presented.

Model formulation
In this paper, we have considered the coronavirus (2019-nCov) pandemic model, proposed in human's population. The whole population is represented with ( ) and is divided into the five compartments as follows: For any time t, the susceptible humans represented as ( ), exposed humans represented as ( ), symptomatic infected humans represented as ( ), asymptomatic infected represented as ( ) and recovered humans represented as ( ). Simply the dynamics of the infection in the population is described through the nonlinear delay differential equations and flow chart is shown in Fig. 1. The parameters of the delayed model are described as follows: is the recruitment rate of humans, is the mortality rate with natural incidences or due to virus infection, 1 is the infection rate of symptomatic humans, 2 is the infection rate of asymptomatic humans, 1 is the interaction rate of exposed humans with symptomatic infected humans, 2 is the interaction rate of exposed humans with asymptomatic infected humans, 3 is the rate of exposed humans who recovered from virus due to natural immunity, 4 is the rate of symptomatic carriers who recovered after quarantine, 5 is the rate of quarantine or isolation or vaccination of asymptomatic infected humans. The given model is based on the following assumptions: considering two ways of dispersion of virus as symptomatic and asymptomatic carriers who make bilinear incidence rate with susceptible humans. Without loss of generality, all types of other interactions have been ignored. The system of delayed differential equations of the model is represented as below: (1) The initial conditions = ( 1 , 2 , 3 , 4 , 5 ) for the Eq.
(1) to (5) is obtained by adding the five equations as follows: + + + + ≤ − and + + + + = . (1) to (5) lie in the feasible region Ω. The feasible region is positive and bounded for the model. Hence, the region Ω is positive invariant.

Equilibria of model
The Eqs.
(1) to (5) admits two equilibria states in the feasible region Ω. A 2019-nCov free equilibrium of the Eqs.

Basic reproduction number
Driekmann et al. [Driekmann, Heesterbeek and Roberts (2009)] presented the idea of reproduction number by using next generation matrix method. From the Eqs.
(1) to (5), we apply the next generation matrix method in order to calculate the reproduction number . We have taken the infectious and recovered human population from the Eqs.

Stability analysis
In this section, stability analysis of the delayed model from Eqs.
(1) to (5) at both 2019-nCov free equilibrium and 2019-nCov recurring equilibrium will be discussed, to check local and global dynamical behaviour of the corona virus, as follows:

Local stability
For the local stability, at both equilibria of the delayed model, we will prove the following well known results as follows: Theorem: For given > 0, the Eqs.

Numerical results
The numerical solutions of Eqs.

Effect of delay factor on reproduction number
In Fig. 5, we have presented the comparison of delay factor and reproduction number. We have concluded that an increase in delaying tactics could change 2019-nCov present equilibrium to 2019-nCov free equilibrium.

Conclusion and directions
Mathematical modelling of epidemiological diseases with the effect of time delay is an important tool to study the disease dynamics. All over the world, we have observed key strategies for overcoming the current disaster of 2019-nCov, delaying tactics or delayed factors. The best uses of the delaying tactics, reduce the 2019-nCov rapidly. The most effective tools for the delay factors are quarantine, isolation, social distancing, immigration restrictions. However, according to the given data, we can use delaying tactics for approximately one hundred and thirteen days to obtain the desired outcomes. Thus, symptomatic infected humans ultimately converge to zero as shown in Fig. 4. For the future work, we can extend this idea to many epidemic diseases and other biological problems. Also, we shall introduce more models of 2019-nCov, in which quarantine, hospitalization, restriction on immigrants' compartments for humans will be considered. This could be a more authentic way to study the 2019-nCov with delay strategy. Furthermore, direction we shall extend this idea to non-linear coupled multiplex networks with multi links and time delay effect as presented by Zhou et al. [Zhou, Tan, Yu et al.