@Article{cju.2026.077071,
AUTHOR = {Zhuoming Xu, Jialu Xin, Weiqing Xu, Guicheng Liu, Liang Dong, Xujun Yu},
TITLE = {The role of specific centrosomal protein dysfunctions in specific sperm defects},
JOURNAL = {Canadian Journal of Urology},
VOLUME = {},
YEAR = {},
NUMBER = {},
PAGES = {{pages}},
URL = {http://www.techscience.com/CJU/online/detail/27186},
ISSN = {1488-5581},
ABSTRACT = {The centrosome is essential for preserving germ-cell integrity across evolution and for safeguarding paternal inheritance in humans. This evolutionarily conserved subcellular structure serves as the primary microtubule-organizing center in mammalian cells, coordinating the assembly of microtubule-based structures that mediate sperm head–neck coupling, flagellar biogenesis and other cytoskeletal rearrangements required for spermatogenesis and early embryogenesis. A rapidly expanding literature now implicates centrosomal proteins in male infertility: structural or functional defects of the centrosome consistently correlate with aberrant sperm morphology, motility failure and distinct pathological phenotypes. The research objective is to review the role of centrosomal protein dysfunctions in specific sperm defects and to discuss their molecular mechanisms and clinical implications for male infertility. Here we review infertility-linked mutations in a select group of centrosomal proteins and dissect their molecular roles in centriole duplication, axonemal assembly and head–neck connection. We outline how pathogenic variants disrupt the spermatogenic program, ultimately producing morphologically abnormal, immotile spermatozoa. Finally, we discuss the clinical utility of these findings for genetic counselling and predictive assessment of male fertility, and we place them in an evolutionary context by highlighting the conserved ultrastructural features of human spermatozoa that depend on an intact centrosome.},
DOI = {10.32604/cju.2026.077071}
}