TY - EJOU AU - Wang, Wenda AU - Wu, Xingcheng TI - The PET/CT manifestations of solitary fibrous tumor of the prostate with prostate cancer: a case report T2 - Canadian Journal of Urology PY - VL - IS - SN - 1488-5581 AB - Backgrounds: Solitary fibrous tumor (SFT) is a rare mesenchymal tumor composed of spindle cells, accounting for less than 2% of all soft tissue tumors. It usually occurs in the visceral pleura but can also arise extrapleurally. However, SFT arising in the prostate is rare. Case Description: A 75-year-old male patient was found to have a space-occupying lesion measuring 4.1 × 3.8 cm located in the left peripheral zone at the base of the prostate. Total prostate-specific antigen (PSA) was 13.2 ng/mL. Prostate needle biopsy revealed histopathological features consistent with prostatic SFT. The patient had received subcutaneous leuprorelin injection for 3 months. At our hospital, both prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) and fibroblast activation protein inhibitor (FAPI) PET/CT demonstrated a lesion in the left peripheral zone of the prostate with increased radiopharmaceutical uptake, without evidence of regional lymph node involvement or distant metastasis. The patient underwent laparoscopic radical prostatectomy under general anesthesia. Postoperative pathological examination confirmed two pathological entities: (1) prostatic adenocarcinoma (Gleason score 3 + 3 = 6) involving left lobe of the prostate; (2) SFT of the prostate. Regular postoperative follow-up has revealed no evidence of recurrence or metastasis to date. Conclusions: Prostatic SFT is extremely rare. The diagnosis depends on the patient’s clinical manifestations, PSA levels, and imaging features, and a prostate biopsy is needed for pathological confirmation. FAPI PET/CT may be useful for the diagnosis of SFT. KW - Solitary fibrous tumor; prostate cancer; fibroblast activation protein inhibitor positron emission tomography/computed tomography (FAPI PET/CT); prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT); case report DO - 10.32604/cju.2026.081697