TY  - EJOU
AU  - Choeypunt, Saraj 
AU  - Siriboonrid, Satit 
AU  - Binsri, Nattapong 
AU  - Jiraanankul, Vittaya 
AU  - Wiriyabanditkul, Weerayut 
AU  - Pattanasuwan, Thanisorn 
AU  - Likitpanpisit, Phatsinee 
AU  - Kanjanatarayon, Sarayut 

TI  - Epinephrine-assisted continuous bladder irrigation after transurethral resection of the prostate: a randomized controlled trial
T2  - Canadian Journal of Urology

PY  - 
VL  - 
IS  - 
SN  - 1488-5581

AB  -  <b>Objectives:</b> Benign prostatic obstruction (BPO) is highly prevalent among aging men. Transurethral resection of the prostate (TUR-P) remains the gold standard therapy; however, postoperative complications such as hematuria and clot retention can impair recovery, prolong hospitalization, and increase the risk of transfusion or infection. This study aimed to evaluate the effect of continuous bladder irrigation (CBI) with epinephrine (CBI-E) on the time to cessation of bladder irrigation following TUR-P, as well as its impact on postoperative outcomes, including length of hospital stay, hematocrit change, irrigation volume, and complications. <b>Methods:</b> This single-center randomized controlled trial was conducted between March 2024 and January 2025. Male patients aged 50–80 years undergoing TUR-P for BPO were randomized to receive postoperative bladder irrigation with either CBI with epinephrine (CBI-E group) or CBI with normal saline (CBI group). The primary outcome was time to cessation of bladder irrigation. Secondary outcomes included hemodynamic parameters, hematocrit change, irrigation volume, postoperative complications, and length of hospital stay. <b>Results:</b> Eighty-five patients were analyzed (CBI-E group, n = 43; CBI group, n = 42). Time to cessation of bladder irrigation was significantly shorter in the CBI-E group (<i>p</i> &lt; 0.001). The CBI-E group also had a shorter length of hospital stay, while hematocrit change and transfusion rates were comparable. No significant hemodynamic instability or serious epinephrine-related adverse events were observed. <b>Conclusion:</b> CBI-E following TUR-P appears to be safe and effectively reduces the time to cessation of bladder irrigation. It is also associated with a shorter hospital stay without increasing postoperative complications.
KW  - transurethral resection of the prostate; continuous bladder irrigation; epinephrine; benign prostatic obstruction

DO  - 10.32604/cju.2026.081532