TY  - EJOU
AU  - Grotas, Aaron B. 
AU  - Nagler, Harris M. 

TI  - Presentation of a functional pituitary adenoma as a significant decrease in prostate-specific antigen level in a patient followed for prostate cancer
T2  - Canadian Journal of Urology

PY  - 2006
VL  - 13
IS  - 6
SN  - 1488-5581

AB  - The stimulatory role of testosterone in the production and
release of prostate-specific antigen (PSA) has been well
characterized. Testosterone production by the testes is
dependent on a functional hypothalamic-pituitary-gonadal
axis. High prolactin levels have been shown to disrupt this
axis, resulting in decreases in gonadotropins and testosterone
levels. We report a patient with prostate cancer and elevated
PSA levels followed with “watchful waiting” for several
years who experienced a precipitous decrease in PSA level
over a 3 month period. The patient was found to have an
asymptomatic prolactin-secreting pituitary macroadenoma.
KW  - prostate specific antigen
KW  -  prolactinoma
KW  -  prostate cancer

DO  -