TY  - EJOU
AU  - Klotz, Laurence H. 

TI  - PSA recurrence: definitions, PSA kinetics, and identifying patients at risk
T2  - Canadian Journal of Urology

PY  - 2006
VL  - 13
IS  - Suppl.2
SN  - 1488-5581

AB  - Uncertainty exists for clinicians and patients with respect
to choosing the optimal therapy for patients with PSA
recurrence. There is no consensus as to what the PSA
cutpoint should be to define PSA failure after radical
prostatectomy (RP) or radiation therapy (XRT). We do,
however, have validated nomograms which allow the
stratification of patients according to their risk of disease
progression and cancer specific death. This is based in
large part on PSA kinetics. A short PSA doubling time
(PSA-DT) is associated with a marked increase in the
risk of prostate cancer death in the 5-10 year time frame.
PSA DT can also be used to identify patients most likely
to respond to local salvage therapy.
KW  - PSA kinetics
KW  -  prostate cancer
KW  -  biochemical failure

DO  -