TY  - EJOU
AU  - Matsuoka, Yoh 
AU  - Arai, Gaku 
AU  - Ishimaru, Hisashi 
AU  - Takagi, Kentaro 
AU  - Ito, Yuji 

TI  - Primary signet-ring cell carcinoma of the prostate
T2  - Canadian Journal of Urology

PY  - 2007
VL  - 14
IS  - 6
SN  - 1488-5581

AB  - We report a rare case of primary signet-ring cell
carcinoma of the prostate in an advanced stage.
A 62-year-old man with serum level of prostate-specific
antigen at 364.70 ng/ml was diagnosed as having
cT4N1M1c prostatic signet-ring cell carcinoma
of Gleason score 5 + 4 = 9. Immunohistochemical
examination demonstrated cytoplasmic immunoreactivity
to prostate-specific antigen in signet-ring cancer cells.
The intracytoplasmic vacuoles in the signet-ring cells
showed mucin production with a positive staining with
periodic acid-Schiff. Although the patient received
hormonal therapy, the disease progressed and lead to death
15 months after the diagnosis. The clinical and
immunohistochemical characteristics of this malignancy
are also reviewed.
KW  - immunohistochemistry
KW  -  mucin
KW  -  prostate cancer
KW  -  prostate-specific antigen
KW  -  signet-ring cell carcinoma

DO  -