TY  - EJOU
AU  - Romics, Imre 
AU  - Székely, Eszter 
AU  - Szendröi, Attila 

TI  - Signet-ring cell carcinoma arising from the urinary bladder
T2  - Canadian Journal of Urology

PY  - 2008
VL  - 15
IS  - 5
SN  - 1488-5581

AB  - <b>Introduction:</b> Signet-ring cell carcinoma of the urinary bladder can be primary — arising from the bladder wall or urachus remnants — or metastatic from tumors originating in the stomach, colon, or breast. Saphir first described primary signet-ring cell cancer of the urinary bladder in 1955. Less than 100 cases have been reported in the literature since then.<br/>
<b>Case report:</b> We report a case of a 45-year-old woman who was admitted with gross hematuria. Cystoscopy revealed a necrotic tumor on the left bladder wall. A transurethral biopsy showed signet-ring cell carcinoma. The bladder tumor was diagnosed as the primary one. Radical cystectomy was performed with ureterosigmoidostomy (Mainz pouch II). Histological examination showed a primary signet-ring cell carcinoma of the bladder (pT3bN0M0). Following surgery, the patient received adjuvant chemotherapy with cisplatin and fluorouracil.<br/>
<b>Conclusions:</b> Primary signet-ring cell carcinoma of the urinary bladder is an extremely rare tumor, accounting for approximately 0.24% of all bladder malignances. Patients with this type of cancer generally have a poor prognosis. However, our patient is free of disease 5 years after radical cystectomy.
KW  - signet-ring cell carcinoma
KW  -  urinary bladder

DO  -