@Article{,
AUTHOR = {Kien T. Mai, Bich Nguyen},
TITLE = {Urothelial carcinoma and prostatic adenocarcinoma presenting as collision  tumors},
JOURNAL = {Canadian Journal of Urology},
VOLUME = {16},
YEAR = {2009},
NUMBER = {5},
PAGES = {4850--4853},
URL = {http://www.techscience.com/CJU/v16n5/62134},
ISSN = {1488-5581},
ABSTRACT = {Urothelial carcinoma (UC) and prostatic adenocarcinoma 
(PAC) commonly occur in elderly patients and share 
common carcinogenic factors that could be identifi ed in the 
urine. The presence of one tumor is known to be associated 
with an increased incidence of the other. Simultaneous 
occurrence of PAC and UC in the prostate is not uncommon; 
however, urinary bladder location of both lesions has not 
yet been reported. Furthermore, invasion into the urinary 
bladder wall by a PAC can also pose a diagnostic challenge 
with UC and other primary urinary bladder tumors. <br/>
We report three patients presenting with UC and PAC 
within the urinary bladder. The patients were 80, 84 
and 85 years old. All patients were diagnosed with high 
grade PAC and either had simultaneous at the initial 
diagnosis or developed UC during the follow up for PAC. 
Histopathological analysis pictured collision tumors 
consisting of an invasive component represented by high 
grade PAC and a superfi cial component composed of low 
or high grade UC. Both components displayed distinctive 
immunophenotypes: PAC was P63- /HMWCK- /PSA+ 
and UC was p63+/HMWCK+/ PSA-.<br/>
In conclusion, awareness of this association is important 
in making the correct diagnosis, especially when dealing 
with urinary bladder biopsy material.},
DOI = {}
}