@Article{,
AUTHOR = {Venu Chalasani, Petr Macek, Gordon F. O’Neill, Wade Barret},
TITLE = {Ureteric stricture secondary to unusual extension of prostatic adenocarcinoma},
JOURNAL = {Canadian Journal of Urology},
VOLUME = {17},
YEAR = {2010},
NUMBER = {1},
PAGES = {5031--5034},
URL = {http://www.techscience.com/CJU/v17n1/62090},
ISSN = {1488-5581},
ABSTRACT = {This article describes an unusual fi nding in a patient who 
presented with an adenocarcinoma of the prostate and right 
hydronephrosis. A 68-year-old male presented with right 
hydronephrosis and a PSA of 96. DRE was consistent with 
cT3 carcinoma. Cystoscopy showed an exophytic superfi cial 
transitional cell carcinoma (TCC) of the bladder and a 
transrectal biopsy of the prostate confi rmed adenocarcinoma 
Gleason score 4+3. Staging investigations (CT pelvis and 
bone scan) were negative; androgen deprivation therapy 
was therefore initiated for the prostatic adenocarcinoma. 
Upper tract imaging showed multiple fi lling defects in the 
proximal ureter. Ureteroscopy showed a stricture at the level 
of the iliac vessels. With a working diagnosis of upper tract 
TCC, right open nephroureterectomy was performed. Final 
histology showed prostatic adenocarcinoma infi ltrating the 
adventitia of the entire ureter up to the level of the renal 
pelvis. <br/>
A rare cause of ureteric stricture, contiguous spread 
of prostatic adenocarcinoma, should be considered in 
the differential diagnosis of patients presenting with 
upper tract obstruction and a known history of prostatic 
adenocarcinoma. Androgen deprivation therapy for several 
months did not seem to cause resolution of the tumour in 
the periureteric, ureteric and perihilar tissues.},
DOI = {}
}