@Article{,
AUTHOR = {Jean F. Wyman, Carl Klutke, Kathryn Burgio, Zhonghong Guan, Franklin Sun, Sandra Berriman, Tamara Bavendam},
TITLE = {Effects of combined behavioral intervention and tolterodine on patient-reported outcomes},
JOURNAL = {Canadian Journal of Urology},
VOLUME = {17},
YEAR = {2010},
NUMBER = {4},
PAGES = {5283--5290},
URL = {http://www.techscience.com/CJU/v17n4/62024},
ISSN = {1488-5581},
ABSTRACT = {<b>Objective:</b> To assess the effects of tolterodine extended release (ER) plus behavioral intervention on urgency and other patient-reported outcomes in subjects with overactive bladder (OAB) who were previously dissatisfied with antimuscarinic treatment.<br/>

<b>Methods:</b> In this 16-week, multicenter, open-label study, eligible adults (aged ≥ 18 y) reported dissatisfaction with their most recent antimuscarinic OAB medication; ≥ 8 micturitions and ≥ 2 urgency episodes per 24 hours and ≥ 1 UUI episode in 5 day bladder diaries; and OAB symptoms for ≥ 3 months. Subjects received tolterodine ER plus a behavioral educational handout with verbal reinforcement of behavioral intervention content for 8 weeks. Those satisfied with treatment at week 8 continued with this therapy; those dissatisfied received tolterodine ER plus individualized behavioral intervention (pelvic floor muscle training, tailored behavioral techniques) for 8 weeks. Endpoints were changes from baseline in daytime and nocturnal micturition-related urgency episodes and frequency-urgency sum (a measure of urgency severity and frequency) reported in 5 day bladder diaries at weeks 4, 8, 12, and 16; Patient Perception of Bladder Condition (PPBC), Overactive Bladder Questionnaire (OAB-q), and Urgency Perception Scale (UPS) scores at weeks 8 and 16.<br/>

<b>Results:</b> Daytime and nocturnal urgency episodes and frequency-urgency sum were significantly reduced at all time points (all p < 0.0001). Significant improvements were also observed in PPBC, OAB-q Symptom Bother and Health-Related Quality of Life, and UPS scores at weeks 8 and 16 (all p < 0.0001).<br/>

<b>Conclusions:</b> Patients with OAB who are dissatisfied with antimuscarinic therapy may experience improved treatment outcomes by adding a self-administered behavioral intervention to their drug regimen.},
DOI = {}
}