TY  - EJOU
AU  - Wyman, Jean F. 
AU  - Klutke, Carl 
AU  - Burgio, Kathryn 
AU  - Guan, Zhonghong 
AU  - Sun, Franklin 
AU  - Berriman, Sandra 
AU  - Bavendam, Tamara 

TI  - Effects of combined behavioral intervention and tolterodine on patient-reported outcomes
T2  - Canadian Journal of Urology

PY  - 2010
VL  - 17
IS  - 4
SN  - 1488-5581

AB  - <b>Objective:</b> To assess the effects of tolterodine extended release (ER) plus behavioral intervention on urgency and other patient-reported outcomes in subjects with overactive bladder (OAB) who were previously dissatisfied with antimuscarinic treatment.<br/>

<b>Methods:</b> In this 16-week, multicenter, open-label study, eligible adults (aged ≥ 18 y) reported dissatisfaction with their most recent antimuscarinic OAB medication; ≥ 8 micturitions and ≥ 2 urgency episodes per 24 hours and ≥ 1 UUI episode in 5 day bladder diaries; and OAB symptoms for ≥ 3 months. Subjects received tolterodine ER plus a behavioral educational handout with verbal reinforcement of behavioral intervention content for 8 weeks. Those satisfied with treatment at week 8 continued with this therapy; those dissatisfied received tolterodine ER plus individualized behavioral intervention (pelvic floor muscle training, tailored behavioral techniques) for 8 weeks. Endpoints were changes from baseline in daytime and nocturnal micturition-related urgency episodes and frequency-urgency sum (a measure of urgency severity and frequency) reported in 5 day bladder diaries at weeks 4, 8, 12, and 16; Patient Perception of Bladder Condition (PPBC), Overactive Bladder Questionnaire (OAB-q), and Urgency Perception Scale (UPS) scores at weeks 8 and 16.<br/>

<b>Results:</b> Daytime and nocturnal urgency episodes and frequency-urgency sum were significantly reduced at all time points (all p < 0.0001). Significant improvements were also observed in PPBC, OAB-q Symptom Bother and Health-Related Quality of Life, and UPS scores at weeks 8 and 16 (all p < 0.0001).<br/>

<b>Conclusions:</b> Patients with OAB who are dissatisfied with antimuscarinic therapy may experience improved treatment outcomes by adding a self-administered behavioral intervention to their drug regimen.
KW  - Overactive bladder
KW  -  behavioral intervention
KW  -  patient-reported outcomes
KW  -  urgency urinary incontinence
KW  -  combination therapy
KW  -  antimuscarinic

DO  -