@Article{,
AUTHOR = {Steve Sterious, Marc C. Smaldone, Elizabeth Plimack, Robert G. Uzzo, Daniel Canter, Alexander Kutikov},
TITLE = {Prolonged natural progression from localized to symptomatic renal cell carcinoma},
JOURNAL = {Canadian Journal of Urology},
VOLUME = {19},
YEAR = {2012},
NUMBER = {6},
PAGES = {6578--6580},
URL = {http://www.techscience.com/CJU/v19n6/61663},
ISSN = {1488-5581},
ABSTRACT = {Surgical excision is the gold standard therapy for clinically 
localized renal masses. Nevertheless, prognostication 
of the natural history of untreated renal cell carcinoma 
(RCC) remains a clinical challenge. While active 
surveillance (AS) has emerged as a viable treatment option 
in select patients with localized tumors and significant 
competing mortality risks, long term follow up data to 
assess the risk of disease progression are limited. We 
present a case of a localized, clinical stage T2 renal mass 
progressing to regional and systemic disease over 6 years, 
demonstrating that kinetics of disease progression may be 
prolonged and are yet to be fully understood.},
DOI = {}
}