@Article{,
AUTHOR = {Navin Shah, Vladimir Ioffe, Anish Kapur},
TITLE = {A comparative analysis of prostate cancer pre-treatment characteristics stratified by age},
JOURNAL = {Canadian Journal of Urology},
VOLUME = {21},
YEAR = {2014},
NUMBER = {2},
PAGES = {7213--7216},
URL = {http://www.techscience.com/CJU/v21n2/61504},
ISSN = {1488-5581},
ABSTRACT = {<b>Introduction:</b> To compare the pretreatment characteristics of prostate cancer, prostate-specific antigen (PSA), digital rectal examination (DRE) and Gleason sum score (GSS) by the American Urological Association (AUA) stratified age groups, <55, 55-69 and ≥70 years old.
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<b>Materials and methods:</b> A retrospective analysis of 402 sequential prostate cancer patients, who had transrectal ultrasound guided 12 core prostate biopsy for either elevated PSA (over 2.5 ng/mL) or positive DRE or both during a three year period, 2010 to 2012. There were 36 patients <55 years, 226 patients 55 to 69 years and 140 patients ≥70 years (range 44-78 years old). This study was conceptualized after the AUA released prostate cancer screening guidelines in which men ≥70 were deleted from screening.
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<b>Results:</b> Overall, compared with patients <70 years old, we found that in patients ≥70 years old: 
1) 60.7% had high GSS (7-10) (p = 0.0234); 2) 39.3% had low GSS (6) (p = 0.0234); 3) 31% had PSA level ≥10 ng/mL (p = 0.0010) and 4) 69.1% had high GSS (7-10) in the presence of a positive DRE (p = 0.0278).
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<b>Conclusion:</b> Patients ≥70 years old had a higher incidence of high GSS (7-10) compared to prostate cancer patients <70 years old. Patients ≥70 years old who also had a positive DRE had the highest incidence of high GSS.},
DOI = {}
}