@Article{,
AUTHOR = {Rajasree Pia Chowdry, Elisa Ledet, Lahiru Ranasinghe, Alton Oliver Sartor},
TITLE = {MLL translocation in two castration-resistant prostate cancer patients},
JOURNAL = {Canadian Journal of Urology},
VOLUME = {23},
YEAR = {2016},
NUMBER = {5},
PAGES = {8483--8486},
URL = {http://www.techscience.com/CJU/v23n5/61130},
ISSN = {1488-5581},
ABSTRACT = {The mixed-lineage leukemia (MLL) protein acts as a histone 
methyltransferase regulating multiple genetic elements. 
Rearrangements of the MLL gene result in expression of 
MLL-fusion proteins that occur in some acute leukemias 
and are associated with poor prognosis. The MLL protein 
complex has been shown to interact with the androgen 
receptor via the MLL-menin subunit, thus promoting 
gene activation. The presence of MLL translocation has 
not been previously reported in patients with castrate 
resistant prostate cancer (CRPC). We describe two cases 
of metastatic CRPC with a translocation in the MLL gene 
detected by a specific fluorescent in situ hybridization 
(FISH) assay. Both patients had an aggressive course 
and succumbed to the illness.},
DOI = {}
}