@Article{,
AUTHOR = {Bryan D. Hinck, Ricardo Miyaoka, James E. Lingeman, Dean G. Assimos, Brian R. Matlaga, Rocky Pramanik, John Asplin, Benjamin Cohen, Manoj Monga},
TITLE = {Urine kidney injury markers do not increase following gastric bypass: a multi-center cross-sectional study},
JOURNAL = {Canadian Journal of Urology},
VOLUME = {25},
YEAR = {2018},
NUMBER = {1},
PAGES = {9199--9204},
URL = {http://www.techscience.com/CJU/v25n1/60888},
ISSN = {1488-5581},
ABSTRACT = {<b>Introduction:</b> This study aims to determine whether markers of kidney injury correlate with urinary oxalate excretion. If such a relationship exists, these biomarkers could serve as early predictors of oxalate nephropathy. Gastric bypass surgery for obesity is known to be associated with postoperative hyperoxaluria, which can lead to urolithiasis and renal damage.<br/>

<b>Materials and methods:</b> Patients were recruited from four large academic medical centers at least six months after undergoing gastric bypass surgery. Participants provided a spot urine sample for analysis of three established biomarkers of kidney injury: 8-iso-Prostaglandin F<sub>2α</sub>, N-acetyl-β-D-glucosaminidase, and neutrophil gelatinase-associated lipocalin. In addition, 24-hour urine samples were collected for stone risk analysis.<br/>

<b>Results:</b> A total of 46 patients participated in the study; the average age was 48.4 ± 11.3 years, with 40 women and 6 men. No significant differences were observed in any of the three kidney injury biomarkers when compared to reference ranges derived from healthy, non-hyperoxaluric subjects. Neither urinary oxalate excretion nor calcium oxalate supersaturation showed a correlation with any of the injury markers. Furthermore, no differences in biomarker levels were found between patients with hyperoxaluria (n = 17) and those with normoxaluria (n = 29).<br/>

<b>Conclusions:</b> Although hyperoxaluria is common following gastric bypass surgery, markers of kidney injury were not elevated in this cohort. Additionally, no correlation was found between urinary oxalate excretion and the evaluated biomarkers of renal injury.},
DOI = {}
}