TY  - EJOU
AU  - Gilling, Peter 
AU  - Barber, Neil 
AU  - Bidair, Mohamed 
AU  - Anderson, Paul 
AU  - Sutton, Mark 
AU  - Aho, Tev 
AU  - Kramolowsky, Eugene 
AU  - Thomas, Andrew 
AU  - Cowan, Barrett 
AU  - Jr., Ronald P. Kaufman, 
AU  - Trainer, Andrew 
AU  - Arther, Andrew 
AU  - Badlani, Gopal 
AU  - Plante, Mark 
AU  - Desai, Mihir 
AU  - Doumanian, Leo 
AU  - Te, Alexis E. 
AU  - DeGuenther, Mark 
AU  - Roehrborn, Claus 

TI  - Three-year outcomes after Aquablation therapy compared to TURP: results from a blinded randomized trial
T2  - Canadian Journal of Urology

PY  - 2020
VL  - 27
IS  - 1
SN  - 1488-5581

AB  - <b>Introduction:</b> To compare 3-year efficacy and safety after prostate resection with Aquablation therapy or transurethral resection of the prostate (TURP) for the treatment of lower urinary tract symptoms related to benign prostate hyperplasia (BPH).<br/>
<b>Materials and methods:</b> One hundred and eighty-one patients assigned to either Aquablation therapy or TURP were followed for 3 years postoperatively. Patients and follow-up assessors were blinded to treatment. Assessments included International Prostate Symptom Score (IPSS), Male Sexual Health Questionnaire (MSHQ-EjD), International Index of Erectile Function (IIEF) and uroflow.<br/>
<b>Results:</b> Over 3 years of treatment, improvements in IPSS scores were statistically similar across groups. Mean 3-year improvements were 14.4 and 13.9 points in the Aquablation and TURP groups, respectively (difference of 0.6 points, 95% CI -3.3–2.2, p = .6848). Similarly, 3-year improvements in Qmax were 11.6 and 8.2 cc/sec (difference of 3.3 [95% CI -0.5-7.1] cc/sec, p = .0848). At 3 years, PSA was reduced significantly in both groups by 0.9 and 1.1 ng/mL, respectively; the reduction was similar across groups (p = .5983). There were no surgical retreatments for BPH beyond 20 months for either Aquablation or TURP.<br/>
<b>Conclusions:</b> Three-year BPH symptom reduction and urinary flow rate improvement were similar after TURP and Aquablation therapy. No subjects required surgical retreatment beyond 20 months postoperatively. (ClinicalTrials.gov number, NCT02505919).
KW  - Aquablation
KW  -  BPH
KW  -  TURP

DO  -