TY  - EJOU
AU  - Desai, Mihir 
AU  - Bidair, Mo 
AU  - Bhojani, Naeem 
AU  - Trainer, Andrew 
AU  - Arther, Andrew 
AU  - Kramolowsky, Eugene 
AU  - Doumanian, Leo 
AU  - Elterman, Dean 
AU  - Jr., Ronald P. Kaufman, 
AU  - Lingeman, James 
AU  - Krambeck, Amy 
AU  - Eure, Gregg 
AU  - Badlani, Gopal 
AU  - Plante, Mark 
AU  - Uchio, Edward 
AU  - Gin, Greg 
AU  - Goldenberg, Larry 
AU  - Paterson, Ryan 
AU  - So, Alan 
AU  - Humphreys, Mitchell R. 
AU  - Roehrborn, Claus G. 
AU  - Kaplan, Steven 
AU  - Motola, Jay 
AU  - Zorn, Kevin C. 

TI  - Aquablation for benign prostatic hyperplasia in large prostates (80-150 cc): 2-year results
T2  - Canadian Journal of Urology

PY  - 2020
VL  - 27
IS  - 2
SN  - 1488-5581

AB  - <b>Introduction:</b> To report 2-year safety and effectiveness of the Aquablation procedure for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) and large-volume 80-150 cc prostates.<br/>
<b>Materials and methods:</b> Between September-December 2017, 101 men with moderate-to-severe BPH symptoms and prostate volumes of 80-150 cc underwent an ultrasound-guided robotically executed Aquablation procedure in a prospective multicenter international clinical trial (WATER II). Baseline, procedural and follow-up parameters were recorded at baseline and scheduled postoperative visits. Herein we report 2-year safety and efficacy for this cohort.<br/>
<b>Results:</b> Mean prostate volume was 107 cc (range 80-150 cc). Mean IPSS improved from 23.2 at baseline to 5.8 at 2 years (17-point improvement, p < .0001). Mean IPSS quality of life improved from 4.6 at baseline to 1.1 at 2 years (p < .0001). Maximum urinary flow increased from 8.7 to 18.2 cc/sec. Two subjects underwent a repeat procedure for BPH symptoms over the 2-year follow-up period. By 2 years or study exit, all but 2 of 74 subjects stopped taking alpha blockers. Similarly, all but 4 of 32 subjects stopped taking 5α-reductase inhibitors.<br/>
<b>Conclusions:</b> Two-year prospective multicenter follow-up demonstrated that the Aquablation procedure is safe and effective in the treatment of men with LUTS due to BPH and prostates 80-150 cc with durable treatment efficacy, acceptable safety profile, and a low retreatment rate. ClinicalTrials.gov number, NCT03123250.
KW  - Aquablation
KW  -  BPH
KW  -  LUTS
KW  -  prostate surgery
KW  -  robotics
KW  -  urology

DO  -