TY  - EJOU
AU  - Faraj, Kassem S. 
AU  - Judge, Nathanael 
AU  - Blodgett, Gail 
AU  - II, Mark D. Tyson 

TI  - Relationship between operative duration and perioperative outcomes after radical cystectomy
T2  - Canadian Journal of Urology

PY  - 2021
VL  - 28
IS  - 2
SN  - 1488-5581

AB  - <b>Introduction:</b> Prolonged operative times have been associated with an increased risk of complications in other major abdominal surgeries. This study tests the hypothesis that longer operative times will be associated with an increased risk of perioperative complications after radical cystectomy (RC).<br/>
<b>Materials and methods:</b> Adult patients who underwent RC from January 1, 2012, through December 31, 2016, were identified from the National Surgical Quality Improvement Program (NSQIP) database. A natural log transformation was used to determine cutoff points for operative times at the 33rd, 67th, and 90th percentiles: 272, 371, and 479 minutes, respectively. Cohorts were divided as follows: A (≤ 272 min), B (273-371 min), C (372-479 min), and D (> 479 min). Multivariable logistic regression analysis was performed to identify associations between operative time and perioperative complications.<br/>
<b>Results:</b> Among 5,610 patients, the distribution across cohorts was: A, 1,993 patients; B, 1,818 patients; C, 1,171 patients; and D, 628 patients. Cohort D had a higher incidence of pulmonary embolism (PE), deep vein thrombosis (DVT), urinary tract infection (UTI), sepsis, 30-day readmission, and blood transfusion rate and had a longer median hospital length of stay. Multivariable analysis showed that operative time (per 60 min increment) was associated with an increased risk of DVT (OR 1.10, p = .04), PE (OR 1.15, p = .01), UTI (OR 1.08, p = .004), readmission (OR 1.04, p = .03), and blood transfusion (OR 1.23, p < .001).<br/>
<b>Conclusions:</b> Longer operative times during RC are associated with a higher rate of perioperative complications. These findings may be confounded by disease stage, surgeon experience, variations in perioperative management protocols, or a combination of these factors.
KW  - bladder cancer
KW  -  urinary diversion
KW  -  cystectomy
KW  -  deep vein thrombosis
KW  -  National Surgical Quality Improvement Program (NSQIP)

DO  -