@Article{,
AUTHOR = {Tawfik Elsherbini, David Bouhadana, Iman Sadri, David-Dan Nguyen, Kyle W. Law, Adel Arezki, Claudia Deyirmendjian, Ahmed Ibrahim, Naeem Bhojani, Dean S. Elterman, Bilal Chughtai, Franck Bruyère, Luca Cindolo, Giovanni Ferrari, Carlos Vasquez-Lastra, Tiago Borelli-Bovo, Edgardo F. Becher, Hannes Cash, Maximillian Reimann, Enrique Rijo, Vincent Misrai, Kevin C. Zorn},
TITLE = {The impact of 5-ARI on perioperative and  functional outcomes of GreenLight PVP: an analysis of the Global GreenLight Group  database},
JOURNAL = {Canadian Journal of Urology},
VOLUME = {30},
YEAR = {2023},
NUMBER = {2},
PAGES = {11473--11479},
URL = {http://www.techscience.com/CJU/v30n2/59719},
ISSN = {1488-5581},
ABSTRACT = {<b>Introduction:</b> In this study, we sought to investigate the impact of 5-alpha reductase inhibitors (5-ARI) on the perioperative and functional outcomes of 180-Watt XPS GreenLight photovaporization of the prostate (PVP) using a large international database.<br/>
<b>Materials and methods:</b> Data were obtained from the Global GreenLight Group (GGG) database, which includes eight high-volume, experienced surgeons from seven international centers. All men with established benign prostatic hyperplasia (BPH) with known 5-ARI status who underwent GreenLight PVP using the XPS-180W system between 2011 and 2019 were eligible for the study. Patients were assigned to two groups based on the preoperative use of 5-ARI. Analyses were adjusted for patient age, prostate volume, and American Society of Anesthesia (ASA) score.<br/>
<b>Results:</b> We included 3,500 men, of which 1,246 (36%) had preoperative 5-ARI use. Patients in both groups were similar with regards to age and prostate size. On multivariable analysis, total operative time was slightly shorter (-3.26 min 95% CI: 1.20 — 5.32, p < 0.01) and required 35.6kJ less laser energy (95% CI: -48.0kJ — -23.3kJ, p < 0.01) for patients on 5ARI compared to those without 5-ARI. However, no clinically significant difference was appreciated regarding postoperative transfusion rates [OR 0.048 (95% CI -0.82-0.91; p = 0.91)], hematuria rates [OR 0.96 (95% CI 0.72-1.3; p = 0.81)], 30-day readmission rates [OR 0.98 (95% CI 0.71-1.4; p = 0.90)], or overall functional outcomes.<br/>
<b>Conclusion:</b> Our findings suggest that preoperative 5-ARI is not associated with any clinically significant different perioperative or functional outcomes for GreenLight PVP using the XPS-180W system. There is no role for the initiation or discontinuation of 5-ARI prior to GreenLight PVP.},
DOI = {}
}