@Article{,
AUTHOR = {Ioana Fugaru, David Bouhadana, Gautier Marcq, Joseph Moryousef, Alexis Rompré-Brodeur, Andrew Meng, Oleg Loutochin, George Loutochin, Maurice Anidjar, Frank Bladou, Rafael Sanchez-Salas},
TITLE = {Partial gland ablation with high intensity focal ultrasound impact on genito-urinary function and quality of life: our initial experience},
JOURNAL = {Canadian Journal of Urology},
VOLUME = {31},
YEAR = {2024},
NUMBER = {1},
PAGES = {11784--11793},
URL = {http://www.techscience.com/CJU/v31n1/59609},
ISSN = {1488-5581},
ABSTRACT = {<b>Introduction:</b> Partial gland ablation (PGA) using high
intensity focal ultrasound (HIFU) is an alternative to
active surveillance for low to intermediate risk localized
prostate cancer. This pilot study assessed quality of life
(QoL) outcomes during the implementation of PGA
HIFU at our institution.<br/>
<b>Materials and methods:</b> We prospectively enrolled
25 men with a diagnosis of localized low/intermediate
risk prostate cancer who elected to undergo PGA-HIFU
in a pilot study at our institution between 2013 and
2016. Patients underwent pre-treatment mpMRI and
transrectal ultrasound-guided biopsies. The primary
endpoints were impact on patient-reported functional
outcomes (erectile, urinary function, QoL) assessed at 1,
3, 6- and 12-months.<br/>
<b>Results:</b> The median age was 64 years old (IQR 59.5
67). Baseline median International Index of Erectile
Function-15 score was 50, which decreased to 18 at 1
month (p < 0.0005), returned to baseline by 3 months
and thereafter. International Prostate Symptom Score
median at baseline was 8, which worsened to 12 at 1
month (p = 0.0088), and subsequently improved to
baseline thereafter. On the UCLA-Expanded Prostate
Cancer Index Composite urinary function, there was a
decrease in median score from 92.7 at baseline to 76.0
at 1 month (p < 0.0001), which improved to or above
baseline afterwards. QoL remained similar to baseline
at each follow up period as assessed by EQ-5D and the
Functional Cancer Therapy-Prostate score.<br/>
<b>Conclusions:</b> In this initial cohort of PGA-HIFU men
at our institution, patients demonstrated a slight, but
transient, deterioration in urinary and erectile function at
1 month prior to normalization. All QoL metrics showed
no impact upon 1 year of follow up post-treatment.},
DOI = {}
}