@Article{,
AUTHOR = {Jack Considine, Kyle O'Hollaren, Codrut Radoiu, Raghav Madan, Aron Liaw, Nivedita Dhar},
TITLE = {Amniotic bladder therapy: six-month follow up treating interstitial cystitis/bladder pain syndrome},
JOURNAL = {Canadian Journal of Urology},
VOLUME = {31},
YEAR = {2024},
NUMBER = {3},
PAGES = {11898--11903},
URL = {http://www.techscience.com/CJU/v31n3/59589},
ISSN = {1488-5581},
ABSTRACT = {<b>Introduction:</b> Interstitial cystitis/bladder pain
syndrome (IC/BPS) is characterized by chronic
pelvic pain and usually accompanies lower urinary
tract symptoms. We have previously reported that
amniotic bladder therapy (ABT) provides symptomatic
improvement in refractory IC/BPS patients for up to 3
months. Herein, we evaluated the durability of ABT
up to 6 months.<br/>
<b>Materials and methods:</b> Consecutive IC/BPS patients
received intra-detrusor injections of 100 mg micronized
amniotic membrane. Clinical evaluation and patient
reported outcome measurements including Interstitial
Cystitis Symptom Index (ICSI), Interstitial Cystitis
Problem Index (ICPI), Bladder Pain/ Interstitial Cystitis
Symptom Score (BPIC-SS) and Overactive Bladder
Assessment Tool (OAB) were assessed.<br/>
<b>Results: </b>Twenty-five consecutive recalcitrant IC/BPS
patients were included in the study with an average age
of 47.4 ± 14.4 years (29-67 years). After ABT, the IC/
BPS symptoms improved gradually up to 3 months in
all patients with an average improvement in ICSI, ICPI,
BPIC-SS and OAB score of 72.8%, 71.9%, and 66.6%,
(p < 0.001) respectively, at 3 months. At 4 months after
ABT, 7 patients experienced a rebound in symptoms and
requested another injection which resulted in a significant
improvement in IC/BPS symptoms after 2, 4, and 8 weeks
(p < 0.01). For the 18 patients who received only one
injection, the IC/BPS symptoms were still significantly
lower at 5 and 6 months compared to baseline (p < 0.01),
suggesting a possible durable effect based on the ICSI,
ICPI, BPIC-SS, and OAB questionnaire scores.<br/>
<b>Conclusions:</b> ABT provided an improvement in pain
and lower urinary tract symptoms up to 6 months post
treatment in some refractory IC/BPS patients.},
DOI = {}
}