@Article{,
AUTHOR = {Bárbara Vieira Lima Aguiar Melão, Sabrina Thalita dos Reis Faria, Kátia Ramos Moreira Leite, Ruan César Aparecido Pimenta, Miguel Srougi, Alberto Azoubel Antunes},
TITLE = {Is there a relationship between testosterone and androgen receptor with prostatectomy outcomes?},
JOURNAL = {Canadian Journal of Urology},
VOLUME = {31},
YEAR = {2024},
NUMBER = {4},
PAGES = {11931--11940},
URL = {http://www.techscience.com/CJU/v31n4/59573},
ISSN = {1488-5581},
ABSTRACT = {<b>Introduction:</b> Prostate cancer has a variable natural history
and, despite the existence of biochemical recurrence (BCR)
predictors, they are still limited in predicting outcomes.
The role of testosterone in advanced prostate cancer is well
known, however its role in localized prostate cancer is still
uncertain. In the present study, we evaluated the relationship
of testosterone levels and androgen receptor (AR) expression
with oncological and functional outcomes, in patients
undergoing radical retropubic prostatectomy (RRP).<br/>
<b>Materials and methods:</b> Through a retrospective
study, patients who underwent RRP, who had at least two
preoperative total testosterone dosages, were analyzed and
compared according to testosterone levels, oncological and
functional outcomes. After analyzing data, tissue samples
were selected in a biorepository to carry out the AR and
the AR-V7 expression. <br/>
<b>Results:</b> After applying exclusion criteria, 212 patients
were included in the analysis. Thirty-two patients
(15.1%) had low testosterone levels and, in this group,
a lower rates of erectile function recovery were observed
at 24 months (53.1% vs. 71.7%; p = 0.037), a higher
rate of BCR (21.9% vs. 9.4%; p = 0.041) and higher
International Society of Urological Pathology (ISUP)
grade in biopsy products. The AR expression was higher
in patients with low testosterone, but there was no
difference in relapse rates.<br/>
<b>Conclusions:</b> Lower levels of testosterone were related
to lower rates of erectile function recovery at the end of 24
months after RRP, in addition to conferring higher rates
of BCR and higher ISUP grades in biopsy. Furthermore,
patients with total testosterone < 300 ng/dL had higher
expression of AR, but no difference in BCR rates.},
DOI = {}
}