@Article{,
AUTHOR = {Daniel Steffens, Cherry Koh, Nicholas Hirst, Ruby Cole, Michael J. Solomon, Lisa Nguyen-Lal},
TITLE = {Prehabilitation in patients undergoing bladder cancer surgery – A systematic review and meta-analysis},
JOURNAL = {Canadian Journal of Urology},
VOLUME = {31},
YEAR = {2024},
NUMBER = {5},
PAGES = {12004--12012},
URL = {http://www.techscience.com/CJU/v31n5/59564},
ISSN = {1488-5581},
ABSTRACT = {<b>Introduction:</b> The evidence on the effectiveness of
prehabilitation in patients undergoing bladder cancer
surgery remains lacking. Thus, the aim of this study is to
determine the effectiveness of prehabilitation on reducing
postoperative morbidity and length of hospital stay in
patients undergoing bladder cancer surgery.<br/>
<b>Materials and methods:</b> This systematic review
included randomized controlled trials investigating
the effect of prehabilitation on postoperative outcomes
in patients undergoing bladder cancer surgery. A
comprehensive search was conducted, with two reviewers
independently screening articles and extracting data. The
Cochrane Collaboration’s tool was used to assess risk of
bias, and GRADE to rate the quality of evidence. When
possible, a random effects meta-analysis was conducted. Estimates were presented as risk ratios or mean differences
with their 95% confidence intervals.<br/>
<b>Results:</b> Of the 2764 articles identified, five trials
comprising 282 patients met the eligibility criteria.
Prehabilitation modalities included preoperative exercise
(3), preoperative nutrition (1), and multimodal (1). The
mean age of patients ranged from 66.0 to 72.1 years. All
included trials presented some or high risk of bias. Pooled
analyses according to the different prehabilitation modalities
demonstrated low to very low quality of evidence of no effect
on postoperative complications and length of hospital stay.<br/>
<b>Conclusion:</b> This study revealed a small number of
trials investigating the effectiveness of prehabilitation
on patients undergoing bladder cancer surgery. Whether
prehabilitation, including preoperative exercise, nutrition
and multimodal interventions reduce postoperative
morbidity and length of hospital stay following bladder
cancer surgery is uncertain, as the quality of evidence is
very low.},
DOI = {}
}