TY - EJOU AU - Mohapatra, Sarbjit AU - Madhekar, Nandkumar AU - Ratkal, Sameer AU - Ratkal, Jaideep TI - Primary renal aspergilloma: a challenge to endure—a case report T2 - Canadian Journal of Urology PY - 2025 VL - 32 IS - 5 SN - 1488-5581 AB - Background: Isolated renal aspergilloma is a rare medical entity posing difficult diagnostic and treatment challenges. Case Description: We document a case of Primary Renal Aspergilloma in a 55-year-old male with diabetes mellitus, hypertension, and chronic liver disease. The individual presented with features of obstructive uropathy due to fungal balls requiring retrograde endoscopic intervention and drainage. The cheesy material retrieved during the procedure was identified as an Aspergilloma on histopathology. Due to far and fewer reports in the medical literature, there have been no standard diagnostic & management strategies, which in turn has resulted in unacceptably high mortality. Conclusion: Isolated renal aspergilloma is an uncommon medical condition with intricate diagnostic and treatment pathways. Due to the rarity of the disease, there is no established protocol for the treatment of renal aspergillomas. Further research is necessary to improve diagnostics, optimize treatments, and enhance clinician awareness for early detection and management. KW - renal aspergilloma; fungal ball; aspergillosis; case report DO - 10.32604/cju.2025.063783