@Article{cju.2025.066758,
AUTHOR = {Jingcheng Lyu, Ruiyu Yue, Yichen Zhu, Ye Tian, Xinyi Hu},
TITLE = {Association of urinary tract infection and low albumin/globulin ratio with chemoresistance to gemcitabine-cisplatin in advanced urothelial carcinoma},
JOURNAL = {Canadian Journal of Urology},
VOLUME = {32},
YEAR = {2025},
NUMBER = {5},
PAGES = {411--422},
URL = {http://www.techscience.com/CJU/v32n5/64370},
ISSN = {1488-5581},
ABSTRACT = { <b>Objective:</b> Urothelial carcinoma (UC) remains a prevalent malignancy with high recurrence and chemoresistance rates despite gemcitabine-cisplatin (GC) chemotherapy. The study aimed to identify clinical risk factors for chemoresistance in advanced UC patients and develop a predictive model. <b>Method:</b> A retrospective analysis was conducted on 375 UC patients who received postoperative GC chemotherapy between 2013 and 2024. Patients were categorized into chemotherapy-resistant (CR, n = 91) and non-chemotherapy resistant (NCR, n = 284) groups based on tumor progression. Clinical, pathological, and laboratory variables were compared using <i>t</i>-tests and chi-square tests. Kaplan-Meier assessed overall survival (OS), and binary logistic regression identified independent predictors of chemoresistance. <b>Result:</b> Overall survival (OS) was significantly lower in the CR group than in the NCR group urinary tract infection (OR: 54.60; 95% CI: [21.19, 140.67]) and low A/G (OR: 0.18;95% CI: [0.03, 0.94]). The prediction model was: Logit(P)=−3.69+0.96×multifocal tumor+1.05×Tstage+4.00×long-termurinary tract infection(UTI)−1.73×A/G. <b>Conclusion:</b> Multifocality, high T stage, persistent UTI, and low A/G ratio are significantly associated with chemoresistance to GC in UC. These routine clinical indicators may support early identification of high-risk patients and guide treatment decisions.},
DOI = {10.32604/cju.2025.066758}
}