@Article{cmes.2018.04076,
AUTHOR = {Long  Deng, Xueying  Huang, Heng  Zuo, Yuan  Zheng, Chun  Yang, Yunhu  Song, Dalin  Tang},
TITLE = {Angle of Attack Between Blood Flow and Mitral Valve Leaflets in Hypertrophic Obstructive Cardiomyopathy: An <i>In Vivo</i> Multi-patient CT-based FSI Study},
JOURNAL = {Computer Modeling in Engineering \& Sciences},
VOLUME = {116},
YEAR = {2018},
NUMBER = {2},
PAGES = {115--125},
URL = {http://www.techscience.com/CMES/v116n2/27412},
ISSN = {1526-1506},
ABSTRACT = {The mechanisms of systolic anterior motion (SAM) of the mitral valve in hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. To investigate the angle of attack between blood flow and mitral valve leaflets at pre-SAM time point, patient-specific CT-based computational models were constructed for 5 patients receiving septal myectomy surgery to obtain pre- and post-operative 2D vector flow mapping. The comparisons between pre- and post-operative angles of attack based on 2D vector flow mapping of 5 patients were performed. It was found that there was no statistically significant difference between pre- and post-operative angles of attack (61.1±t wao vs. 56.2±56.o, p=0.306, n=5). Therefore, we propose that the angle of attack might not play an important role in the initiation of SAM.},
DOI = {10.31614/cmes.2018.04076}
}