TY - EJOU AU - Deng, Long AU - Huang, Xueying AU - Zuo, Heng AU - Zheng, Yuan AU - Yang, Chun AU - Song, Yunhu AU - Tang, Dalin TI - Angle of Attack Between Blood Flow and Mitral Valve Leaflets in Hypertrophic Obstructive Cardiomyopathy: An In Vivo Multi-patient CT-based FSI Study T2 - Computer Modeling in Engineering \& Sciences PY - 2018 VL - 116 IS - 2 SN - 1526-1506 AB - The mechanisms of systolic anterior motion (SAM) of the mitral valve in hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. To investigate the angle of attack between blood flow and mitral valve leaflets at pre-SAM time point, patient-specific CT-based computational models were constructed for 5 patients receiving septal myectomy surgery to obtain pre- and post-operative 2D vector flow mapping. The comparisons between pre- and post-operative angles of attack based on 2D vector flow mapping of 5 patients were performed. It was found that there was no statistically significant difference between pre- and post-operative angles of attack (61.1±t wao vs. 56.2±56.o, p=0.306, n=5). Therefore, we propose that the angle of attack might not play an important role in the initiation of SAM. KW - Hypertrophic obstructive cardiomyopathy KW - systolic anterior motion KW - mitral valve leaflets KW - computational model KW - angle of attack DO - 10.31614/cmes.2018.04076