@Article{cmes.2019.07159,
AUTHOR = {Jie Bai, Liqiang Lin, Xiaowei Zeng},
TITLE = {Computational Study of Collective Cell Migration By Meshfree Method},
JOURNAL = {Computer Modeling in Engineering \& Sciences},
VOLUME = {121},
YEAR = {2019},
NUMBER = {3},
PAGES = {787--800},
URL = {http://www.techscience.com/CMES/v121n3/38069},
ISSN = {1526-1506},
ABSTRACT = {The collective cell migration behavior on a substrate was studied using RKPM
meshfree method. The cells were modeled as nematic liquid crystal with hyperelastic cell
nucleus. The cell-substrate and cell-cell interactions were modeled by coarse-grained
potential forces. Through this study, the pulling and pushing phenomenon during collective
cell migration process was observed and it was found that the individual cell mobility
significantly influenced the collective cell migratory behavior. More self-propelled cells
are in the system along the same direction, the faster the collective group migrates toward
coordinated direction. The parametric study on cell-cell adhesion strength indicated that as
the adhesion strength increases, the collective cell migration speed increases. It also
showed that the mechanical stress in leader cell is higher than stress in follower cells. },
DOI = {10.32604/cmes.2019.07159}
}