@Article{cmes.2020.08527,
AUTHOR = {M. Al-Saad, C. A. Suarez, A. Obeidat, S. P. A. Bordas, S. Kulasegaram},
TITLE = {Application of Smooth Particle Hydrodynamics Method for Modelling Blood Flow with Thrombus Formation},
JOURNAL = {Computer Modeling in Engineering \& Sciences},
VOLUME = {122},
YEAR = {2020},
NUMBER = {3},
PAGES = {831--862},
URL = {http://www.techscience.com/CMES/v122n3/38377},
ISSN = {1526-1506},
ABSTRACT = {Thrombosis plays a crucial role in atherosclerosis or in haemostasis when a 
blood vessel is injured. This article focuses on using a meshless particle-based Lagrangian 
numerical technique, the smoothed particles hydrodynamic (SPH) method, to study the 
flow behaviour of blood and to explore the flow parameters that induce formation of a 
thrombus in a blood vessel. Due to its simplicity and effectiveness, the SPH method is
employed here to simulate the process of thrombogenesis and to study the effect of various 
blood flow parameters. In the present SPH simulation, blood is modelled by two sets of 
particles that have the characteristics of plasma and of platelet, respectively. To simulate 
coagulation of platelets which leads to a thrombus, the so-called adhesion and aggregation 
mechanisms of the platelets during this process are modelled by an inter-particle force 
model. The transport of platelets in the flowing blood, platelet adhesion and aggregation 
processes are coupled with viscous blood flow for various low Reynolds number scenarios. 
The numerical results are compared with the experimental observations and a good 
agreement is found between the simulated and experimental results.},
DOI = {10.32604/cmes.2020.08527}
}