@Article{cmes.2022.016957,
AUTHOR = {Cemile Bagkur, Emrah Guler, Bilgen Kaymakamzade, Evren Hincal, Kaya Suer},
TITLE = {Near Future Perspective of ESBL-Producing <i>Klebsiella pneumoniae</i> Strains Using Mathematical Modeling},
JOURNAL = {Computer Modeling in Engineering \& Sciences},
VOLUME = {130},
YEAR = {2022},
NUMBER = {1},
PAGES = {111--132},
URL = {http://www.techscience.com/CMES/v130n1/45708},
ISSN = {1526-1506},
ABSTRACT = {While antibiotic resistance is becoming increasingly serious today, there is almost no doubt that more challenging times await us in the future. Resistant microorganisms have increased in the past decades leading to limited treatment options, along with higher morbidity and mortality. <i>Klebsiella pneumoniae</i> is one of the significant microorganisms causing major public health problems by acquiring resistance to antibiotics and acting as an opportunistic pathogen of healthcare-associated infections. The production of extended spectrum beta-lactamases (ESBL) is one of the resistance mechanisms of <i>K. pneumoniae</i> against antibiotics. In this study, the future clinical situation of ESBL-producing <i>K. pneumoniae</i> was investigated in order to reflect the future scenarios to understand the severity of the issue and to determine critical points to prevent the spread of the ESBL-producing strain. For evaluation purposes, SIS-type mathematical modeling was used with retrospective medical data from the period from 2016 to 2019. Stability of the disease-free equilibrium and basic reproduction ratios were calculated. Numerical simulation of the SIS model was conducted to describe the dynamics of non-ESBL and ESBL-producing <i>K. pneumoniae.</i> In order to determine the most impactful parameter on the basic reproduction ratio, sensitivity analysis was performed. A study on mathematical modeling using data on ESBL-producing <i>K. pneumoniae</i> strains has not previously been performed in any health institution in Northern Cyprus, and the efficiency of the parameters determining the spread of the relevant strains has not been investigated. Through this study, the spread of ESBL-producing <i>K. pneumoniae</i> in a hospital environment was evaluated using a different approach. According to the study, in approximately seventy months, ESBL-producing <i>K. pneumoniae</i> strains will exceed non-ESBL <i>K. pneumoniae</i> strains. As a result, the analyses showed that hospital admissions and people infected with non-ESBL or ESBL-producing <i>K. pneumoniae</i> have the highest rate of spreading the infections. In addition, it was observed that the use of antibiotics plays a major role in the spread of ESBL-producing <i>K. pneumoniae</i> compared to other risk factors such as in-hospital transmissions. As a matter of course, recoveries from <i>Klebsiella</i> infections were seen to be the most effective way of limiting the spread. It can be concluded from the results that although the use of antibiotics is one of the most effective factors in the development of the increasing ESBL-producing <i>K. pneumoniae</i>, regulation of antibiotic use policy could be a remedial step together with effective infection control measures. Such steps may hopefully lead to decreased morbidity and mortality rates as well as improved medical costs.},
DOI = {10.32604/cmes.2022.016957}
}