TY  - EJOU
AU  - Hanasaki, Itsuo  
AU  - Shintaku, Hirofumi  
AU  - Kawano, Satoshi Matsunami, Satoyuki  

TI  - Structural and Tensile Properties of Self-Assembled DNA Network on Mica Surface
T2  - Computer Modeling in Engineering \& Sciences

PY  - 2009
VL  - 46
IS  - 2
SN  - 1526-1506

AB  - Self-assembly is one of the physical phenomena that are promising for the manufacturing process of the devices on which DNA molecules are mounted as the components. We have conducted a structural study of self-assembled poly(dA)\discretionary poly(dT) DNA networks on mica surface to discuss the design requirements. The results indicate that the network formation process consists of the adsorption and the subsequent coarsening. The final form of the component filaments are roughly straight. These characteristics imply the possible tensile loads during the network formation. Therefore, we have conducted molecular dynamics simulations of tensile tests of a short DNA fragment to elucidate the relevant mechanical properties. The effective tensile properties strongly depend on the loading condition of the clamp, which can affect the functionality of the molecules.
KW  - DNA
KW  -  substrate
KW  -  self-assembly
KW  -  network structure
KW  -  biodevice
KW  -  molecular dynamics

DO  - 10.3970/cmes.2009.046.191