TY  - EJOU
AU  - J.A.Ferreira, 
AU  - Oliveira, P.  
AU  - Silva, P.M.  
AU  - Carreira, A.  
AU  - Murta, J.N.  

TI  - Sustained Drug Release from Contact Lenses
T2  - Computer Modeling in Engineering \& Sciences

PY  - 2010
VL  - 60
IS  - 2
SN  - 1526-1506

AB  - This paper focuses on the release of an ophthalmic drug (flurbiprofen) from a loaded copolymer where the drug is simultaneously dispersed in the polymeric matrix and entrapped in particles.
The copolymer is based in 2-hydroxyethyl methacrylate co-methacrylic acid and silicone is used to prepare the loaded particles. A mathematical model to simulate the drug release is proposed and a qualitative analysis is performed. In vitro experimental results are compared with simulation results. Contact lens made from the presented copolymer are expected to deliver drug at therapeutical levels for a few days.
KW  - Ophthalmic drug delivery
KW  -  contact lenses
KW  -  p-(HEMA/MAA)
KW  -  reaction-diffusion equation
KW  -  qualitative behavior
KW  -  in vitro experiments
KW  -  simulation results

DO  - 10.3970/cmes.2010.060.151