@Article{,
AUTHOR = {Vincent L. Butty, Pascale Roux-Lombard, Jorge Garbino, Jean-Michel Dayer, Bara Ricou, and the Geneva Sepsis Network (participating members are listed in the appendix)},
TITLE = {Anti-inflammatory response after infusion of p55 soluble tumor necrosis factor receptor fusion protein for severe sepsis},
JOURNAL = {European Cytokine Network},
VOLUME = {14},
YEAR = {2003},
NUMBER = {1},
PAGES = {15--19},
URL = {http://www.techscience.com/ECN/v14n1/66547},
ISSN = {1952-4005},
ABSTRACT = {Objectives: To investigate the effects of Lenercept®, a recombinant soluble TNF receptor p55 fused
to an immunoglobulin heavy chain IgG<sub>1</sub>, on the balance of pro- and anti-inflammatory mediators in sepsis.<br/>
Design: Post hoc analysis of a subgroup of patients enrolled in a multicenter phase III, prospective, double-blind,
placebo-controlled, randomized study of Lenercept
® in severe sepsis.<br/>
Setting: Surgical and medical intensive care units, and postoperative recovery room of a tertiary care teaching
hospital.<br/>
Patients: A total of 57 patients were enrolled in the multicenter study in our center.<br/>
Intervention: Septic patients were randomly assigned to receive either Lenercept
® 0.125 mg/kg or placebo. The
patients were followed for up to 28 days after randomization.<br/>
Measurements and main results: Circulating levels of TNF-α, IL-6, TNFsR<sub>75</sub> and IL-1Ra were measured before
and after treatment. The two groups were comparable with regard to age, gender and diagnosis distribution. The
total level of TNF-α increased significantly in treated patients, compared to patients receiving placebo. The levels
of the other inflammatory mediators did not differ between the two groups.<br/>
Conclusions: Lenercept
®-treated patients experienced a protracted TNF-a half-life, leading to higher total TNF-α
levels throughout the study. However, the treatment had no effects on anti-inflammatory mediators. Therefore,
peripheral inflammatory processes might not have been significantly modified by the treatment. This might
account for the lack of efficacy this treatment in septic patients.},
DOI = {}
}