@Article{,
AUTHOR = {Laura Brandolini, Marcello Allegretti, Valerio Berdini, Maria Neve Cervellera, Patrizia Mascagni, Matteo Rinaldi, Gabriella Melillo, Pietro Ghezzi, Manuela Mengozzi, Riccardo Bertini},
TITLE = {Carbocysteine lysine salt monohydrate (SCMC-LYS) is a selective scavenger of reactive oxygen intermediates (ROIs)},
JOURNAL = {European Cytokine Network},
VOLUME = {14},
YEAR = {2003},
NUMBER = {1},
PAGES = {20--26},
URL = {http://www.techscience.com/ECN/v14n1/66548},
ISSN = {1952-4005},
ABSTRACT = {Carbocysteine lysine salt monohydrate (SCMC-Lys) is a well-known mucoactive drug whose
therapeutic efficacy is commonly related to the ability of SCMC-Lys to replace fucomucins by sialomucins. The
aim of this study was to determine if SCMC-Lys could exert an anti-oxidant action by scavenging reactive oxygen
intermediates (ROIs). Our results show that SCMC-Lys proved effective as a selective scavenger of hypochlorous
acid (HOCl) and hydroxyl radical (OH•
), this effect being related to the reactivity of the SCMC tioether group.
The scavenger activity of SCMC-Lys was observed in free cellular system as well as in activated human
polymorphonuclear neutrophils (PMNs). SCMC-Lys scavenger activity on HOCl was paralleled by a powerful
protection from HOCl-mediated inactivation of a1-antitripsin (a1-AT) inhibitor, the main serum protease
inhibitor. Production of interleukin-(IL-)8, a major mediator of PMN recruitment in inflammatory diseases, is
known to be mediated by intracellular OH•
. SCMC-Lys significantly reduced IL-8 production on stimulated
human peripheral blood mononuclear cells (PBMCs) in the same range of concentrations affecting OH• activity.
It is concluded that SCMC-Lys could exert, in addition to its mucoactive capacity, an anti-oxidant action, thus
contributing to the therapeutic efficacy of SCMC-Lys.},
DOI = {}
}