@Article{,
AUTHOR = {Trawat Attarbaschi, Martin Willheim, Michael Ramharter, Andrea Hofmann, Katharina Wahl, Heidi Winkler, Wolfgang Graninger, Stefan Winkler},
TITLE = {T cell cytokine profile during primary Epstein-Barr virus infection (infectious mononucleosis)},
JOURNAL = {European Cytokine Network},
VOLUME = {14},
YEAR = {2003},
NUMBER = {1},
PAGES = {34--39},
URL = {http://www.techscience.com/ECN/v14n1/66550},
ISSN = {1952-4005},
ABSTRACT = {Cytokine profiles of CD4<sup>+</sup> and CD8<sup>+</sup> T-cell subsets were evaluated in 8 patients with infectious
mononucleosis (IM). Intracellular detection of cytokines using flow cytometry revealed an expansion of
IFN-γ-expressing CD4<sup>+</sup> T cells, and particularly CD8<sup>+</sup> T cells, while IL-2 expressing cells were less frequently
encountered when compared to healthy controls. Single TNF-α-expressing CD4<sup>+</sup> and CD8<sup>+</sup> T cells were likewise
reduced and shifted towards IFN-γ/TNF-α co-production. The predominant pro-inflammatory type 1-biased
immune response during IM was emphasized by low frequencies of IL-10 expression in both T cell subsets,
although some patients displayed elevated serum levels. Six months later, a decreased, but still elevated IFN-γ
expression within the CD8<sup>+</sup> T cell subset, and an increased percentage of IL-2-expressing CD4<sup>+</sup> and CD8<sup>+</sup> T cells,
reaching values shown for controls, were noted. Type 2-associated cytokines such as IL-4 and IL-13, as well as
IL-6 and TNF-α were not significantly different when compared to controls at study entry and at follow-up. The
striking expansion of IFN-γ-producing CD8<sup>+</sup> T cells with rather low expression of IL-10, appears to be a key
factor for clinically overt disease, but is nevertheless compatible with successful control of the viral infection.},
DOI = {}
}