@Article{,
AUTHOR = {M. D. Rodríguez-Arnao, A. Rodríguez-Sánchez, J. Rodríguez-Arnao, E. Dulín-Íñiguez, J. M. Bellón Cano, M. A. Muñoz-Fernández},
TITLE = {Undetectable levels of tumor necrosis factor-a, nitric oxide and inadequate expression of inducible nitric oxide synthase in congenital hypothyroidism},
JOURNAL = {European Cytokine Network},
VOLUME = {14},
YEAR = {2003},
NUMBER = {1},
PAGES = {63--68},
URL = {http://www.techscience.com/ECN/v14n1/66554},
ISSN = {1952-4005},
ABSTRACT = {Objetive: To analyse the production of TNF-α and NO in euthyroid and hypothyroid newborns.<br/>
Patients: A cross-sectional study was conducted involving 10 newborns diagnosed with primary congenital
hypothyroidism (CH; group A) and 10 euthyroid children (group B).<br/>
Results: There were undetectable plasma levels of TNF-α and NO in the hypothyroid children, however plasma
levels of TNF-α (5.5 ± 0.5 pg/ml) and NO (5.6 ± 1.7 µM) were detected at normal levels in all euthyroid children.
Moreover, expression of iNOS mRNA in PBMC, determined by RT-PCR, was negative in both groups of infants.<br/>
Conclusion: TNF-α and NO production are both impaired in hypothyroid newborns. We report for the first time
evidence of undetectable levels of TNF-α and NO in infants with CH.},
DOI = {}
}