@Article{,
AUTHOR = {Silvia Di Loreto, Rita Maccarone, Luigi Corvetti, Pierluigi Sebastiani, Daniela Piancatelli, Domenico Adorno},
TITLE = {Differential modulation of interleukin-6 expression by interleukin-1β in neuronal and glial cultures},
JOURNAL = {European Cytokine Network},
VOLUME = {14},
YEAR = {2003},
NUMBER = {2},
PAGES = {97--102},
URL = {http://www.techscience.com/ECN/v14n2/66542},
ISSN = {1952-4005},
ABSTRACT = {We analysed the specific effects of IL-1β immunoneutralization on the expression of IL-6 in different
pure cultures of neurones and glia after both experimental subliminal hypoxia and recovery. Whereas the
IL-1β-deprivation signal induced a decrease in IL-6 expression and release of normoxic neurones, it provoked an
increase in IL-6 protein in hypoxic neurones. Moreover, the direct correlation between IL-1β and IL-6, observed
in normal and recovering neuronal cultures, was reversed in hypoxic conditions. These reversals were not
observed in glial cells, in which IL-1β immunosuppression led to a decrease in IL-6 under all conditions
considered. In conclusion, the IL-1β modulates IL-6 in different ways according to the ambient physiological or
pathological conditions, and also acts via different mechanisms, depending on the cellular phenotype.},
DOI = {}
}