TY  - EJOU
AU  - Loreto, Silvia Di 
AU  - Maccarone, Rita 
AU  - Corvetti, Luigi 
AU  - Sebastiani, Pierluigi 
AU  - Piancatelli, Daniela 
AU  - Adorno, Domenico 

TI  - Differential modulation of interleukin-6 expression by interleukin-1β in neuronal and glial cultures
T2  - European Cytokine Network

PY  - 2003
VL  - 14
IS  - 2
SN  - 1952-4005

AB  - We analysed the specific effects of IL-1β immunoneutralization on the expression of IL-6 in different
pure cultures of neurones and glia after both experimental subliminal hypoxia and recovery. Whereas the
IL-1β-deprivation signal induced a decrease in IL-6 expression and release of normoxic neurones, it provoked an
increase in IL-6 protein in hypoxic neurones. Moreover, the direct correlation between IL-1β and IL-6, observed
in normal and recovering neuronal cultures, was reversed in hypoxic conditions. These reversals were not
observed in glial cells, in which IL-1β immunosuppression led to a decrease in IL-6 under all conditions
considered. In conclusion, the IL-1β modulates IL-6 in different ways according to the ambient physiological or
pathological conditions, and also acts via different mechanisms, depending on the cellular phenotype.
KW  - IL-1β
KW  -  IL-6
KW  -  neurones
KW  -  glia
KW  -  hypoxia

DO  -