@Article{,
AUTHOR = {Neslihan Bukan, Sinan Sözen, Ugur Coskun, Banu Sancak, Nazan Günel, Ibrahim Bozkırlı, Çagrı Senocak},
TITLE = {Serum interleukin-18 and nitric oxide activity in bladder carcinoma},
JOURNAL = {European Cytokine Network},
VOLUME = {14},
YEAR = {2003},
NUMBER = {3},
PAGES = {163--167},
URL = {http://www.techscience.com/ECN/v14n3/66533},
ISSN = {1952-4005},
ABSTRACT = {Background: Both interleukin-18 and nitric oxide are multifunctional molecules that are involved
in the different steps of carcinogenesis.<br/>
Methods: In the present study, we measured serum interleukin-18 and nitric oxide activity in 51 bladder cancer
patients with different tumor stage and grade, and in 8 healthy controls. Serum nitrite-nitrate levels were
measured as an index of nitric oxide generation.<br/>
Results: Serum interleukin-18 levels were significantly higher in bladder cancer patients when compared to the
control subjects (p > 0.05). Serum interleukin-18 levels were found to be higher in patients with Ta stage than
patients with T1 and T2, T3, T4 stages and in patients with grade 1 tumors than patients with grade 2 and grade
3 tumors, but this was not statistically significant (p > 0.05). There was no significant difference in serum
nitrite + nitrate levels between bladder cancer patients and control subjects.<br/>
Conclusions: Elevated serum interleukin-18 levels in bladder carcinoma patients may be a result of host defence
mechanism against the growth and progression of bladder cancer cells.},
DOI = {}
}