@Article{,
AUTHOR = {Carita Eklund, Farhana Jahan, Tanja Pessi, Terho Lehtimäki, Mikko Hurme},
TITLE = {Interleukin 1B gene polymorphism is associated with baseline C-reactive protein levels in healthy individuals},
JOURNAL = {European Cytokine Network},
VOLUME = {14},
YEAR = {2003},
NUMBER = {3},
PAGES = {168--171},
URL = {http://www.techscience.com/ECN/v14n3/66534},
ISSN = {1952-4005},
ABSTRACT = {C-reactive protein (CRP) is a sensitive marker of inflammation induced by both IL-6 and IL-1.
Thus, genetic variation in these genes could be associated with the variety in C-reactive protein levels, and
therefore with the severity of the entire inflammatory response. Even a subtle elevation in baseline CRP levels in
healthy individuals has been found to significantly increase the risk for cardiovascular diseases. Therefore, to find
out the possible role of pro-inflammatory cytokines in CRP baseline regulation we conducted a study of
338 healthy blood donors whose CRP levels were determined and whose single nucleotide polymorphisms of
IL1A(C/T)-889, IL1B(C/T)-511, IL1B(C/T) + 3954, IL6(G/C)-174 and ILRN (a VNTR) both genotyped and
haplotyped. The data revealed an association between CRP levels and the IL1B + 3954 genotype. Also, the bilocus
haplotype IL1B-511*1/IL1B + 3954*2 was more frequent in subjects with below median CRP levels (< 0.72 mg/l),
and composite genotype analysis of IL1B-511/IL1B + 3954 supported this finding. Our findings suggest that in
healthy people, basal CRP levels are regulated by IL1B but not by IL6 genetics.},
DOI = {}
}