@Article{,
AUTHOR = {Catharina Suharti, Eric C. M. van Gorp, Wil M. V. Dolmans, Tatty E. Setiati, C. Erik Hack, Robert J. Djokomoeljanto, Jos W. M. van der Meer},
TITLE = {Cytokine patterns during dengue shock syndrome},
JOURNAL = {European Cytokine Network},
VOLUME = {14},
YEAR = {2003},
NUMBER = {3},
PAGES = {172--177},
URL = {http://www.techscience.com/ECN/v14n3/66535},
ISSN = {1952-4005},
ABSTRACT = {Objective. To investigate the patterns of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β),
IL-6, interferon-γ (IFN-γ) and interleukin-1 receptor antagonist (IL-1Ra) during the course of dengue shock
syndrome.<br/>
Design. Prospective clinical study.<br/>
Setting. Pediatric Intensive Care Unit, Dr. Kariadi Hospital, the university hospital of Diponegoro University,
Semarang, Indonesia.<br/>
Patients. Fifty children with dengue shock syndrome.<br/>
Measurements. The plasma concentration and the ex vivo production, with and without lipopolysaccharide (LPS),
of TNF-α, IL-1β and IL-1Ra were measured in duplicate by nonequilibrium radioimmunoassay (RIA); IFN-γ and
IL-6 were measured by ELISA.
Results. During the acute phase, the plasma concentrations and the ex vivo production without LPS of IL-1Ra
were considerably elevated and returned to normal on recovery. However, the ex vivo LPS-stimulated production
of the proinflammatory cytokines TNF-α and IL-1β were considerably depressed. Also, these concentrations
returned towards normal on recovery. In non-survivors, the plasma concentrations of IL-6 and IL-1Ra were
significantly higher than in survivors (p < 0.00001 and p = 0.0005, respectively). In addition, the ex vivo production
of IL-1Ra in non-survivors was significantly higher than in survivors, both without LPS stimulation (p = 0.0008)
and with LPS (p < 0.004). IL-1Ra was significantly associated with mortality (p = 0.007).<br/>
Conclusion. Since IL-1Ra was significantly associated with mortality, this measurement may be used as an index
of disease severity in dengue shock syndrome.},
DOI = {}
}