@Article{,
AUTHOR = {Saadou Issifou, Elie Mavoungou, Steffen Borrmann, Marielle K. Bouyou-Akotet, Pierre-Blaise Matsiegui, Peter G. Kremsner, Francine Ntoumi},
TITLE = {Severe malarial anemia associated with increased soluble Fas ligand (sFasL) concentrations in Gabonese children},
JOURNAL = {European Cytokine Network},
VOLUME = {14},
YEAR = {2003},
NUMBER = {4},
PAGES = {238--241},
URL = {http://www.techscience.com/ECN/v14n4/66522},
ISSN = {1952-4005},
ABSTRACT = {To investigate if severe malarial anemia is associated with specific cytokine overproduction, we
evaluated serum levels of soluble Fas ligand (sFasL), tumor necrosis factor (TNF-α) and interleukin-10 (IL-10)
from three groups of young children with <i>Plasmodium falciparum</i> infection (asymptomatic cases, uncomplicated
malaria cases and severe malarial anemia cases), in a hyperendemic area of Gabon. In uncomplicated cases, only
TNF levels were significantly (p < 0.001) increased in comparison to asymptomatic cases with <i>P. falciparum</i>
infection. High levels of sFasL, TNF-α and IL-10 were associated with low hemoglobin concentrations, sFasL
levels were significantly higher in children with severe malarial anemia (p < 0.001) as compared to both other
groups. The parasite density was positively correlated with IL-10, TNF-α and sFasL levels. TNF-α and sFasL, but
not IL-10 or parasitemia, were independent predictors of hemoglobin concentrations. These results suggest that,
in malaria, a specific dysregulation of the cytokine balance may lead to complications such as severe anemia.},
DOI = {}
}