TY  - EJOU
AU  - Almendro, Vanessa 
AU  - Carbó, Neus 
AU  - Busquets, Sílvia 
AU  - Figueras, Maite 
AU  - Tessitore, Luciana 
AU  - López-Soriano, Francisco J. 
AU  - Argilés, Josep M. 

TI  - Sepsis induces DNA fragmentation in rat skeletal muscle
T2  - European Cytokine Network

PY  - 2003
VL  - 14
IS  - 4
SN  - 1952-4005

AB  - Recent studies have demonstrated the activation of skeletal muscle DNA fragmentation in some
catabolic conditions [1]. In an attempt to elucidate if sepsis (a catabolic state) was also associated with muscle
apoptosis, sepsis was induced by cecal ligation and puncture, and the results clearly show an induction of DNA
fragmentation in gastrocnemius muscle following the induction of the septic state. Administration of rolipram (an
inhibitor of tumour necrosis factor-a (TNF-α) synthesis) to septic rats clearly prevented the increased DNA
fragmentation, suggesting that TNF-α is involved in the activation of the apoptotic events in septic rat skeletal
muscle.
KW  - sepsis; cecal ligation; skeletal muscle; DNA fragmentation; TNF-α; apoptosis

DO  -