TY - EJOU AU - Witkowska, Anna Maria AU - Borawska, Maria Halina TI - Soluble intercellular adhesion molecule-1 (sICAM-1): an overview T2 - European Cytokine Network PY - 2004 VL - 15 IS - 2 SN - 1952-4005 AB - Soluble intercellular adhesion molecule-1 (sICAM-1) represents a circulating form of ICAM-1 that is constitutively expressed or is inducible on the cell surface of different cell lines. It serves as a counter-receptor for the lymphocyte function-associated antigen (LFA-1). Interaction between ICAM-1, present on endothelial cells, and LFA-1 facilitates leukocyte adhesion and migration across the endothelium. ICAM-1 and its circulating form have been implicated in the development of any number of diseases. KW - sICAM-1; cancers; atherosclerosis; autoimmune diseases; nutrition DO -