@Article{,
AUTHOR = {Jean-Jacques Lataillade, Jorge Domenech, Marie-Caroline Le Bousse-Kerdilès},
TITLE = {Stromal cell-derived factor-1 (SDF-1)/CXCR4 couple plays multiple roles on haematopoietic progenitors at the border between the old cytokine and new chemokine worlds: survival, cell cycling and trafficking},
JOURNAL = {European Cytokine Network},
VOLUME = {15},
YEAR = {2004},
NUMBER = {3},
PAGES = {177--188},
URL = {http://www.techscience.com/ECN/v15n3/66371},
ISSN = {1952-4005},
ABSTRACT = {Generation of haematopoietic cells is regulated by cellular and humoral interactions in which
stromal cells, adhesion molecules, cytokines and chemokines play a crucial role. Among the chemokines, SDF-1
and its CXCR4 receptor have been reported to be key players in the nesting of haematopoietic progenitors within
the bone marrow. Disruption of the SDF-1/CXCR4 axis results in cell mobilization and may participate in
leukaemia extramedullary infiltration. In this review we will discuss the manifold roles of the SDF-1 chemokine
and of its receptor in haematopoiesis regulation. By recruiting quiescent progenitors, by participating in their
survival/cycling and by sensitizing them to further cytokine synergistic action, SDF-1 likely contributes to
haematopoiesis homeostasis under physiological conditions and in stress situations. The complexity of the
SDF-1/CXCR4 interactions in the regulation of haematopoiesis illustrates a dynamic and sequential cross-talk
between chemokine and cytokine/growth factor worlds. Because of their pleiotropic effects on haematopoietic
progenitor trafficking, survival and proliferation, the SDF-1/CXCR4 couple could be considered as promising
molecules for improvement of cell-based therapy protocols in haematopoietic transplantation.},
DOI = {}
}