@Article{,
AUTHOR = {Michael Ramharter, Peter G. Kremsner, Martin Willheim, Heidi Winkler, Wolfgang Graninger, Stefan Winkler},
TITLE = {<i>Plasmodium falciparum</i>-specific interleukin-2 and tumor necrosis factor-α expressing-T cells are associated with resistance to reinfection and severe malaria in healthy African children},
JOURNAL = {European Cytokine Network},
VOLUME = {15},
YEAR = {2004},
NUMBER = {3},
PAGES = {189--196},
URL = {http://www.techscience.com/ECN/v15n3/66373},
ISSN = {1952-4005},
ABSTRACT = {The frequency of <i>P. falciparum</i>-specific interleukin (IL)-2-, interferon (IFN)-γ-, tumor necrosis
factor (TNF)-α- and IL-10-expressing CD3<sup>+</sup> cells was studied in healthy Gabonese children segregated according
to their clinical presentation at admission to a longitudinal study of severe and mild malaria. The percentage of
IL-2- and TNF-α- expressing <i>P. falciparum</i>-specific CD3<sup>+</sup> cells was significantly higher in the children with prior
mild malaria and less frequent reinfections compared to the children with prior severe malaria and more frequent
reinfections. No differences were shown for <i>P. falciparum</i>-specific IFN-γ and IL-10 expression within CD3<sup>+</sup> cells
and parasite-non-specific expression of IL-2, IL-4, IL-6, IL-10, IL-13, TNF-α, and IFN-γ within the CD4<sup>+</sup>
, CD8<sup>+</sup>
,
TCRγ/δ<sup>+</sup> CD3<sup>+</sup> and CD94<sup>+</sup> CD3<sup>–</sup> cell populations, indicating that immunological determinants regulating the
susceptibility to malaria in age-matched children are parasite-specific. The ability of <i>P. falciparum</i>-specific T cells
to mount a rapid IL-2 and TNF-α response might be of significance in preventing severe disease and reinfection.},
DOI = {}
}