@Article{,
AUTHOR = {Clara de Andrés, M. Carmen Rodríguez-Sáinz, M. Angeles Muñoz-Fernández, Nieves López-Lazareno, Margarita Rodríguez-Mahou, Angeles Vicente, Eduardo Fernández-Cruz, Silvia Sánchez-Ramón},
TITLE = {Short-term sequential analysis of sex hormones and helper T cells type 1 (Th1) and helper T cells type 2 (Th2) cytokines during and after multiple sclerosis relapse},
JOURNAL = {European Cytokine Network},
VOLUME = {15},
YEAR = {2004},
NUMBER = {3},
PAGES = {197--202},
URL = {http://www.techscience.com/ECN/v15n3/66374},
ISSN = {1952-4005},
ABSTRACT = {Multiple sclerosis (MS) is an immune-mediated disease with a clear sex-bias that may be attributed
to sex hormones, sex’ linked genes or both. Here we sought to determine the evolution pattern of cortisol and sex
hormones at MS relapse and 2-months later in 7 male patients with relapsing remitting MS, and whether there
was a correlation with a specific Th1 and Th2 cytokine pattern. Our findings indicate the activation of the
hypothalamic-pituitary-adrenal axis and the concomitant upregulation of pro- and anti-inflammatory cytokines
during relapse. The further increase of sex hormones, in particular estradiol in our male MS patients suggest their
possible implication in the physiopathology of the illness and a putative anti-inflammatory and neuroreparatory
effect.},
DOI = {}
}